SAN FRANCISCO (AP) — Edwin Jackson became the first player in major league history to play for 14 teams when he made his Toronto Blue Jays debut and pitched five innings Wednesday in a 4-3 loss to the San Francisco Giants.

The 35-year-old right-hander allowed three runs — two earned — and six hits in five innings. He struck out two, walked one, hit a batter and left after 77 pitches with the score 3-3.

Brandon Crawford hit a tiebreaking home run in the sixth off Ryan Tepera (0-2).

Mark Melancon (1-0) pitched out of a first-and-third, no-outs jam in the sixth for the win. Will Smith struck out the side in the ninth to remain perfect in 11 save chances.

Toronto acquired Jackson from Oakland on Saturday for $30,000. He began his tenure with his new team by throwing an 88 mph cutter that Joe Panik took for a called strike.

Jackson had been tied with Octavio Dotel for most teams. Jackson agreed last month to a minor league contract with the A’s and was 1-0 with a 6.75 ERA in three minor league starts.

Swipe below to see photos of the game.

In addition to the Blue Jays and Athletics, Jackson has played for the Los Angeles Dodgers, Tampa Bay, Detroit, Arizona, the Chicago White Sox, St. Louis, Washington, the Chicago Cubs, Atlanta, Miami, San Diego and Baltimore.

Toronto has four starting pitchers on the injured list, including right-handers Clay Buchholz (shoulder) and Matt Shoemaker (out for the season after knee surgery), and left-handers Ryan Borucki (elbow) and Clayton Richard (right knee).

Jackson, who made his 306th big league start, is 104-123 in 17 big league seasons.

He gets paid at the rate of a $2 million salary while in the majors and can earn $500,000 in performance bonuses based on starts: $150,000 each for 15 and 18, and $200,000 for 20.

Aramis Garcia also homered for San Francisco.

Toronto leadoff hitter Brandon Drury singled and scored three runs. Vladimir Guerrero Jr. walked and had an RBI groundout in four plate appearances, one day after the 20-year-old becoming the third-youngest player to hit his first two major league home runs in the same game.

Freddy Galvis hit an RBI double in the first, but Jackson gave up a run-scoring double to Pablo Sandoval in the bottom half. Garcia hit a two-run homer in the second after right fielder Billy McKinney dropped Kevin Pillar’s short fly ball for an error.

Giants starter Shaun Anderson also gave up three runs — two earned — in five innings but allowed just two hits. He throw a run-scoring wild pitch in the third and allowed Guerrero’s tying grounder in the fifth.

MOVES

Toronto LHP Thomas Pannone was optioned to Triple-A Buffalo after going 1-3 with a 6.85 ERA in 14 games for the Blue Jays. RHP David Phelps and Shoemaker were transferred to the 60-day IL. Toronto also claimed RHP Jimmy Cordero off of waivers from Washington and optioned him to Buffalo. Cordero has not pitched in the majors this season. The 27-year-old was 1-2 with a 5.68 ERA in 22 games with the Nationals in 2018.

TRAINER’S ROOM

Giants: 1B Brandon Belt was rested because of a sore right knee. With an off day Thursday, the hope is that the inflammation in Belt’s knee will go down. … RHP Johnny Cueto is expected to throw a 40-pitch bullpen Saturday in Arizona.

UP NEXT

Blue Jays: RHP Marcus Stroman (1-6, 3.12 ERA) makes his second straight start against the White Sox when Toronto begins a four-game series in Chicago on Thursday. Stroman allowed three runs in 6 1/3 innings and took the loss on Saturday.

Giants: RHP Jeff Samardzija (2-1, 3.51) pitches against Arizona on Friday for the first time since 2017. Samardzija has struggled this season and has made it past five innings twice in eight starts.

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