UCD Researchers Close To Developing Vaccine For Salmonella

DAVIS (CBS13) – Researchers at UC Davis say they’re getting close to a vaccine to prevent a food borne illness that can sometimes kill.

Scientists at the UC Davis Center for Comparative Medicine are developing a vaccine against salmonella, the increasingly antibiotic-resistant bacteria, that kills hundreds of thousands of people worldwide each year.

Stephen McSorley is leading the international team of researchers who have fanned out around the world and includes infected children in Africa.

Salmonella kills one in four African children and researchers fear those numbers will rise without a cure.

“To design a vaccine for young kids in Africa that are infected with the salmonated, it’s exactly the same type of salmonella that causes gastroenteritis in the U.S. but happens to cause a more serious infection in African children,” McSorley said.

The three-year project is close to completion. Researchers at UC Davis are using mice to help develop the shot.

“Our hope is by understanding the immune response in mice at various infections, we can apply that information to human diseases,” explained McSorley. “From that information we can use that to design a new vaccine for salmonella. And we’re not quite there yet, but we’re working towards that.”

The latest research from UC Davis was just published in the National Academy of Sciences.

Researchers say the study would not have been possible without grants from the National Institute of Health.

  • mmm999

    Vaccines contain a number of substances which can be divided into the following groups:

    1. Micro-organisms, either bacteria or viruses, thought to be causing certain infectious diseases and which the vaccine is supposed to prevent. These are whole-cell proteins or just the broken-cell protein envelopes, and are called antigens.

    2. Chemical substances which are supposed to enhance the immune response to the vaccine, called adjuvants.

    3. Chemical substances which act as preservatives and tissue fixatives, which are supposed to halt any further chemical reactions and putrefaction (decomposition or multiplication) of the live or attenuated (or killed) biological constituents of the vaccine.

    All these constituents of vaccines are toxic, and their toxicity may vary, as a rule, from one batch of vaccine to another.


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